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Search Result

Search Results for " ppar γ "

Targets

PPAR

27

Compounds

12

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T22708 Darglitazone CP-86325 PPAR
Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions. Darglitazone is effective in controlling blood glucose and lipid metabolism.
T1461 Candesartan CV 11974 RAAS
Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.
TQ0156 GW1929 PPAR
GW1929 is a potent PPAR-γ agonist (pKi: 8.84 for human PPAR-γ; pEC50s of 8.56 and 8.27 for human and murine PPAR-γ).
T15575 Indeglitazar PPM 204 PPAR
Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).
T27303 Farglitazar GI-262570,GI-2570,GW 262570X,GI 262570,GI262570 PPAR
Farglitazar (GI-262570) is a PPAR-γ agonist and insulin sensitizer that inhibits stellate cell activation by activating receptor γ via oxidative enzymes proliferators and is used in the study of diabetes.
T21587 Muraglitazar Pargluva,BMS-298585 PPAR
Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα and PPARγ with EC50 of 320 nM and 110 nM r...
T8780 AMG131 INT-131,AMG-131,CHS 131 PPAR
AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatment of type 2 diabetes mellitus (non-insulin depende...
T16739 RG-12525 NID 525 Leukotriene Receptor , PPAR
RG-12525（NID 525） is an orally available, selective and competitive leukotriene D (LTD) antagonist that inhibits LTC4, LTD4 and LTE4-induced contraction of guinea pig thin-walled bands, with IC50 values of 2.6 nM, 2.5 nM...
T7621 6-​Thioinosine 6-Mercaptopurine riboside,6TI Nucleoside Antimetabolite/Analog
6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.
T16022 Arhalofenate JNJ 39659100,MBX 102 PPAR
Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.
T17044 Tesaglitazar PPAR
Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα and human PPARα were 13.4 μM and 3.6 μM, respectively, and 0...
T27513 GW7845 GW 7845,GW-7845
GW7845, an L-tyrosine derivative, is a PPAR-γ agonist.
T10506 PPAR agonist 1 PPAR
PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.
T33415 MK 0767 MK0767,MK-0767
MK 0767 is a dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist that has been investigated as a potential treatment for type 2 diabetes and dyslipidemia.
T10596 BR102375 Others
BR102375 is a non-TZD PPAR γ full agonist (EC50: 0.28 μM) for the treatment of type 2 diabetes.
T28542 Rivoglitazone HCl CI-1037,CI1037,CS011,CS-011,CI 1037
Rivoglitazone, also known as CI-1037; CS-011; DE-101; R-119702; Rivo, is a peroxisome proliferator-activated receptor γ agonist (PARPγ agonist) potentially for the treatment of type 2 diabetes. Rivoglitazone has been sho...
T81120 SP4f PPAR
SP4f, an activator of PPAR-γ, exhibits an EC50 value of 826 nM in HK-2 cells. In Swiss albino mice, it diminishes blood glucose levels and lipid peroxidation while enhancing glutathione levels and catalase activity [1].
T81121 SP4e PPAR
SP4e, a PPAR-γ activator, exhibits an EC50 of 739 nM in HK-2 cells. In Swiss albino mice, it diminishes blood glucose and lipid peroxidation while enhancing glutathione levels and catalase activity [1].
T79231 DSO-5a PPAR
DSO-5a, a potent and selective orally active BB3 agonist, is a DMAKO-00 derivative that enhances ppar-γ activity via BB3 and stimulates ERK1/2 phosphorylation. It is utilized in diabetes-related research [1].
T62576 Darglitazone Sodium
Darglitazone Sodium is a thiazolidinedione, a selective, orally active PPAR-γ (peroxisome proliferator-activated receptor) agonist, which can be used in the study of type II diabetes as it effectively controls glucose an...
T28589 Ro 41-5253 Ro-41-5253,Ro 415253 Apoptosis , Retinoid Receptor
Ro 41-5253 is an orally active RARα antagonist, ligand and partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ. It exhibits antitumor activity, inhibits proliferation and induces apoptosis in MCF-7 and...
T78582 15-keto-Prostaglandin E2 15-keto-PGE2 Prostaglandin Receptor
15-keto-Prostaglandin E2, an endogenous metabolite, inhibits STAT3 activation through binding to Cys259 and regulates breast cancer cell growth and progression. Additionally, it binds and stabilizes the EP2 and EP4 recep...
T37579 GW 1929 hydrochloride
Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and tr...
T37829 CAY10573
The peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors often used as drug targets for the treatment of metabolic disorders. CAY10573 is a PPAR agonist that displays potent bindi...
T61976 DS-6930
DS-6930 is an potent and selective PPAR γ Agonists with EC50 of 41 nM. DS-6930 can effectively reduce plasma glucose (PG) level, and has less PPARγ-related adverse effects compared with Rosiglitazone. DS-6930 has researc...
T69671 SR1903 TFA
SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated rec...
T35813 CAY10592
Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharm...
Cat No. Product Name Synonyms Targets
T1633 β-Carotene Carotaben,Beta-Carotene,Provitamin A Apoptosis , ROS , Endogenous Metabolite
β-Carotene (Provitamin A) is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene...
T6S0117 Avicularin Fenicularin ERK
Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX...
TN1693 Glabrone Influenza Virus , PPAR
Glabrone shows antiviral activity against influenza virus.
T2946 Tanshinone IIA sulfonate sodium Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium CaMK , P450 , Calcium Channel
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor...
T2932 Ginsenoside Rh1 Sanchinoside B2,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1 IL Receptor , TNF , Endogenous Metabolite , PPAR , Interleukin
Ginsenoside Rh1 (Sanchinoside B2) , one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
TN1018 Angeloylgomisin H PPAR
Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines.
TN2601 12-O-Methylcarnosic acid Reductase
12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from Salvia microphylla, is an active constituent of 5α-Reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid has Antioxidant activity...
T4956 Tetrahydroxystilbene-2-O-β-D-glucoside tetrahydroxyl diphenylethylene-2-o-gluco,EH-201 Others
Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-β-D-glucoside induces expression of erythropoietin, PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astroc...
T3867 Alpinetin (-)-alpinetin BCL , PPAR
Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeutic agent CDDP. Alpinetin has strong anti-he...
TN4860 Pueroside B COX , PPAR
Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A rece...
TN3219 7,8-Didehydrocimigenol ERK , IκB/IKK , TNF , NF-κB , Akt , PPAR
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of V...
TN3655 Cimiside E ERK , TNF , ROS , Akt , PI3K , PKC , PPAR
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.Cimiside E may b...

Natural Products

β-Carotene
T1633
Synonym: Carotaben,Beta-Carotene,Provitamin A
Target: Apoptosis, ROS, Endogenous Metabolite
Avicularin
T6S0117
Synonym: Fenicularin
Target: ERK
Glabrone
TN1693
Synonym:
Target: Influenza Virus, PPAR
Tanshinone IIA sulfonate sodium
T2946
Synonym: Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium
Target: CaMK, P450, Calcium Channel
Ginsenoside Rh1
T2932
Synonym: Sanchinoside B2,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1
Target: IL Receptor, TNF, Endogenous Metabolite, PPAR, Interleukin
Angeloylgomisin H
TN1018
Synonym:
Target: PPAR
12-O-Methylcarnosic acid
TN2601
Synonym:
Target: Reductase
Tetrahydroxystilbene-2-O-β-D-glucoside
T4956
Synonym: tetrahydroxyl diphenylethylene-2-o-gluco,EH-201
Target: Others
Alpinetin
T3867
Synonym: (-)-alpinetin
Target: BCL, PPAR
Pueroside B
TN4860
Synonym:
Target: COX, PPAR
7,8-Didehydrocimigenol
TN3219
Synonym:
Target: ERK, IκB/IKK, TNF, NF-κB, Akt, PPAR
Cimiside E
TN3655
Synonym:
Target: ERK, TNF, ROS, Akt, PI3K, PKC, PPAR

Recombinant Proteins

Species：
Human (1)
Expression System：
Baculovirus Insect Cells (1)
Tag：
His, GST (1)
Cat No. Product Name Species Expression System
TMPY-02575 PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling even...
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